PROTAC KRAS G12D degrader 2
PROTAC KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPro) . Protac KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPRO) . The PROTAC molecule is designed by partially coupling a GC-376-based dipeptidyl 3CLPro ligand with pomadomide via a piperazine-piperidine linker[1].
Product Specifications
UNSPSC
12352005
Target
PROTACs; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/protac-kras-g12d-degrader-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@H](/C=C/C(N1CCN(CC2CCN(C3=C(F)C=C(C(N(C(CCC(N4)=O)C4=O)C5=O)=O)C5=C3)CC2)CC1)=O)C[C@@H]6CCNC6=O)=O)OCC7=CC=CC=C7
Molecular Formula
C46H57FN8O9
Molecular Weight
884.99
References & Citations
[1]Grifagni D, et al. Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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