Antimalarial agent 37

Antimalarial agent 37 (compound 33) is a selective inhibitor against Type II kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7[1].

Product Specifications

CAS Number

[2982633-16-7]

UNSPSC

12352005

Target

Ephrin Receptor; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antimalarial-agent-37.html

Solubility

10 mM in DMSO

Smiles

CCN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC(C3=CC(NC(C4=CC(C5=CC=CS5)=CN=C4)=O)=CC(C(F)(F)F)=C3)=O

Molecular Formula

C32H29F6N5O2S

Molecular Weight

661.66

References & Citations

[1]Wang L, et al., Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. J Med Chem. 2024 Jan 12. doi: 10.1021/acs.jmedchem.3c02046