Antimalarial agent 37
Antimalarial agent 37 (compound 33) is a selective inhibitor against Type II kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7[1].
Product Specifications
CAS Number
2982633-16-7
UNSPSC
12352005
Target
Ephrin Receptor; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antimalarial-agent-37.html
Solubility
10 mM in DMSO
Smiles
CCN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC(C3=CC(NC(C4=CC(C5=CC=CS5)=CN=C4)=O)=CC(C(F)(F)F)=C3)=O
Molecular Formula
C32H29F6N5O2S
Molecular Weight
661.66
References & Citations
[1]Wang L, et al., Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. J Med Chem. 2024 Jan 12. doi: 10.1021/acs.jmedchem.3c02046
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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