TP0628103
TP0628103 (compound 18) is a selective inhibitor of MMP-7, with the IC50 value of 0.17 nM that plays an important role in cancer and fibrosis[1].
Product Specifications
CAS Number
2865102-08-3
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tp0628103.html
Solubility
10 mM in DMSO
Smiles
CC(C)([C@@H](C(NC1=CC=C(C(N2CCC(C(N[C@@H](C(N3CC[C@@H](C3)N)=O)CCCCN)=O)CC2)=O)C=C1)=O)NC([C@@H](NC(CNC(CC[C@@H](C(O)=O)NS(=O)(C4=CC(C(F)(F)F)=C(Cl)C=C4)=O)=O)=O)CC5=CC=NC=C5)=O)C
Molecular Formula
C51H67ClF3N11O11S
Molecular Weight
1134.66
References & Citations
[1]Yusuke Oka, et al. Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points. J Med Chem. 2024 Jan 12. doi: 10.1021/acs.jmedchem.3c01967.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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