TP0628103

TP0628103 (compound 18) is a selective inhibitor of MMP-7, with the IC50 value of 0.17 nM that plays an important role in cancer and fibrosis[1].

Product Specifications

CAS Number

[2865102-08-3]

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tp0628103.html

Solubility

10 mM in DMSO

Smiles

CC(C)([C@@H](C(NC1=CC=C(C(N2CCC(C(N[C@@H](C(N3CC[C@@H](C3)N)=O)CCCCN)=O)CC2)=O)C=C1)=O)NC([C@@H](NC(CNC(CC[C@@H](C(O)=O)NS(=O)(C4=CC(C(F)(F)F)=C(Cl)C=C4)=O)=O)=O)CC5=CC=NC=C5)=O)C

Molecular Formula

C51H67ClF3N11O11S

Molecular Weight

1134.66

References & Citations

[1]Yusuke Oka, et al. Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points. J Med Chem. 2024 Jan 12. doi: 10.1021/acs.jmedchem.3c01967.