ATAG 2139

ATAG 2139 (CFT-2139) is an aTAG-based MTH1 fusion protein degrader with a DC50 value of 1.1 nM. aTAG 2139 has a Ki value of 2.1 nM for MTH1[1].

Product Specifications

CAS Number

[2387510-81-6]

Product Name Alternative

CFT-2139

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/atag-2139.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C2=CC=C3N=CC(C(NC)=O)=C(C3=C2)NC4=CC=CC=C4)C=N1)NCCCCNC(COC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O

Molecular Formula

C42H38N8O8

Molecular Weight

782.80

References & Citations

[1]Veits G K, et al. Development of an AchillesTAG degradation system and its application to control CAR-T activity[J]. Current Research in Chemical Biology, 2021, 1: 100010.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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