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HDAC6-IN-31

HDAC6-IN-31 (compound 8m) is a selective HDAC6 inhibitor, with the IC50 value of 0.026 μM, that significantly inhibits the production and release of pro-inflammatory cytokines. While HDAC6 is critically involved in the activation of inflammasomes, HDAC6-IN-31 has the potential to inhibit NLRP3 inflammasome-driven inflammatory diseases. HDAC6-IN-31 also inhibits glioblastoma cell migration[1].

Product Specifications

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hdac6-in-31.html

Solubility

10 mM in DMSO

Smiles

FC1=C(NC2=C(C)N=C3N2C=CC=C3)C=CC(C(NO)=O)=C1

Molecular Formula

C15H13FN4O2

Molecular Weight

300.29

References & Citations

[1]Kraft FB, et al. Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties. Bioorg Chem. 2024 Feb;143:107072.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; HDAC6

Frequently Asked Questions

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