AChE/BChE-IN-17
AChE/BChE-IN-17 (compound 8m) is a potent and non-competitiveAChE and BChE inhibitor, with IC50 values of 125.06 nM and 119.68 nM, respectively. AChE/BChE-IN-17 also inhibits α-glucosidase, with an IC50 of 41050 nM[1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bche-in-17.html
Solubility
10 mM in DMSO
Smiles
O=[N+]([O-])C1=CC=C2C(N=C(/C(CCC3)=C/C4=CC=C(OC)C=C4)C3=C2NC5=CC=C(OC)C=C5)=C1
Molecular Formula
C28H25N3O4
Molecular Weight
467.52
References & Citations
[1]Shirisha T, et al. Metal-free synthesis of functionalized tacrine derivatives and their evaluation for acetyl/butyrylcholinesterase and α-glucosidase inhibition. Org Biomol Chem. 2024 Jan 3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
Frequently Asked Questions
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