EGFR/microtubule-IN-1
EGFR/microtubule-IN-1 (Compound 10c) is a dual inhibitor targeting EGFR and tubulin. The IC50 for inhibiting EGFR is 10.66 nM. EGFR/microtubule-IN-1 can reduce the phosphorylation levels of EGFR, AKT and ERK, hinder tubulin polymerization, and induce apoptosis[1].
Product Specifications
CAS Number
1970269-96-5
UNSPSC
12352005
Target
Apoptosis; EGFR; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-microtubule-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC(NC1=C(OC)C=C(N=CN=C2NC3=CC=C(Br)C=C3)C2=C1)=O)C4=CC=CC=C4
Molecular Formula
C23H18BrN5O3
Molecular Weight
492.32
References & Citations
[1]Liu Y, et al. Design of balanced dual-target inhibitors of EGFR and microtubule. Bioorg Chem. 2024 Feb;143:107087.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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