EGFR/c-Met-IN-2
Product Specifications
UNSPSC Description
EGFR/ C-Met-in-2 (Compound H-22) is a dual inhibitor of EGFR/c-Met. EGFR/c-Met-IN-2 inhibits cell proliferation by arresting G2/M phase. EGFR/c-Met-IN-2 has antitumor activity[1].
Target Antigen
c-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-c-met-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C=C)NC(C(OC)=C1)=CC2=C1N=CN=C2OC3=CC=C(NC(NCCC4=CC=C(F)C=C4)=O)C=C3F
Molecular Weight
519.50
References & Citations
[1]Zhang H, et al. Novel quinazoline-based dual EGFR/c-Met inhibitors overcoming drug resistance for the treatment of NSCLC: Design, synthesis and anti-tumor activity. Bioorg Chem. 2024 Jan;142:106938.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161141/EGFR-c-Met-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161141/
Clinical Information
No Development Reported
CAS Number
2761180-01-0
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