EGFR/c-Met-IN-2

EGFR/ C-Met-in-2 (Compound H-22) is a dual inhibitor of EGFR/c-Met. EGFR/c-Met-IN-2 inhibits cell proliferation by arresting G2/M phase. EGFR/c-Met-IN-2 has antitumor activity[1].

Product Specifications

CAS Number

[2761180-01-0]

UNSPSC

12352005

Target

C-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-c-met-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(C=C)NC(C(OC)=C1)=CC2=C1N=CN=C2OC3=CC=C(NC(NCCC4=CC=C(F)C=C4)=O)C=C3F

Molecular Formula

C27H23F2N5O4

Molecular Weight

519.50

References & Citations

[1]Zhang H, et al. Novel quinazoline-based dual EGFR/c-Met inhibitors overcoming drug resistance for the treatment of NSCLC: Design, synthesis and anti-tumor activity. Bioorg Chem. 2024 Jan;142:106938.