Lenalidomide 4'-PEG2-amine (dihydrochloride)
Lenalidomide 4'-PEG2-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG2-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1].
Product Specifications
CAS Number
[2624336-88-3]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lenalidomide-4-peg2-amine-dihydrochloride.html
Purity
98.96
Solubility
DMSO : 70 mg/mL (ultrasonic)
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2)C(NCCOCCOCCN)=CC=C3)=O)=O.Cl.Cl
Molecular Formula
C19H28Cl2N4O5
Molecular Weight
463.36
References & Citations
[1]Wang S, et al. Monofunctional intermediates for ligand-dependent target protein degradation. China, WO2017176958A1. 2017-10-12.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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