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(+) -JQ1-OH

(+) -JQ1-OH is the major metabolite of (+) -JQ1. (+) -JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4 (1/2) ). (+) -JQ-1 also activates autophagy[1].

Product Specifications

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/plus-jq1-oh.html

Solubility

10 mM in DMSO

Smiles

OCC(S1)=C(C)C2=C1N3C([C@H](CC(OC(C)(C)C)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C

Molecular Formula

C23H25ClN4O3S

Molecular Weight

472.99

References & Citations

[1]Holmes S, et al. Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1. ACS Med Chem Lett. 2024;15 (1) :107-115. Published 2024 Jan 2.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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