Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

(+) -JQ1-OH

(+) -JQ1-OH is the major metabolite of (+) -JQ1. (+) -JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4 (1/2) ). (+) -JQ-1 also activates autophagy[1].

Product Specifications

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/plus-jq1-oh.html

Solubility

10 mM in DMSO

Smiles

OCC(S1)=C(C)C2=C1N3C([C@H](CC(OC(C)(C)C)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C

Molecular Formula

C23H25ClN4O3S

Molecular Weight

472.99

References & Citations

[1]Holmes S, et al. Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1. ACS Med Chem Lett. 2024;15 (1) :107-115. Published 2024 Jan 2.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Tissue Total RNA, Ovary: right
CR560883 5 µg

Tissue Total RNA, Ovary: right

Sign In for Pricing
View Details
PAK5 (NM_177990) Human Recombinant Protein
TP723910 100 µg

PAK5 (NM_177990) Human Recombinant Protein

Sign In for Pricing
View Details
Neurofilament (NF-L) (NR-4), CF740 conjugate, 0.1mg/mL
BNC740303-100 1x 100 µL

Neurofilament (NF-L) (NR-4), CF740 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Spectrin beta III (SPTBN2) (SPTBN2/2979R), CF640R conjugate, 0.1mg/mL
BNC402979-100 1x 100 µL

Spectrin beta III (SPTBN2) (SPTBN2/2979R), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details
PE/Elab Fluor® 594 Anti-Mouse CD45R/B220 Antibody[RA3.3A 1/6.1]
E-AB-F1112P-01 50 Tests

PE/Elab Fluor® 594 Anti-Mouse CD45R/B220 Antibody[RA3.3A 1/6.1]

Sign In for Pricing
View Details
PE/Elab Fluor® 594 Anti-Mouse CD45R/B220 Antibody[RA3.3A 1/6.1]
E-AB-F1112P-02 100 Tests

PE/Elab Fluor® 594 Anti-Mouse CD45R/B220 Antibody[RA3.3A 1/6.1]

Sign In for Pricing
View Details