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Drpitor1a

Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer[1][2].

Product Specifications

CAS Number

[73326-98-4]

UNSPSC

12352005

Target

Dynamin; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/drpitor1a.html

Purity

96.95

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(C(C=CC=C3)=C3N2)C(C4=CN=CC=C41)=O

Molecular Formula

C15H8N2O2

Molecular Weight

248.24

References & Citations

[1]Wu D, et al. Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury. FASEB J. 2020 Jan;34 (1) :1447-1464. |[2]Wu D, et al. Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572836.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-161119/Drpitor1a-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-161119/Drpitor1a-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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