MB327

MB327 is a bipyridine nonoxime compound that restores neuromuscular function. MB327 restores the activity of nicotinamide acetylcholine receptors (nAChRs) for carbachol desensitization in a typical type II PAM manner. MB327 can neutralize nerve agent poisoning[1][2].

Product Specifications

CAS Number

[61368-98-7]

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mb327.html

Solubility

10 mM in DMSO

Smiles

CC(C)(C)C1=CC=[N+](CCC[N+]2=CC=C(C(C)(C)C)C=C2)C=C1.[I-].[I-]

Molecular Formula

C21H32I2N2

Molecular Weight

566.30

References & Citations

[1]Niessen K V, et al. In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2-and 3-regioisomers[J]. Toxicology Letters, 2018, 293: 190-197.|[2]Seeger T, et al. Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro[J]. Toxicology, 2012, 294 (2-3) : 80-84.