AD-8007

AD-8007 is an acetyl CoA synthase 2 (ACSS2) inhibitor that can cross the blood-brain barrier. AD-8007 can significantly reduce lipid storage and cell colony formation in vitro models, and increase tumor cell death. AD-8007 has anti-cancer activity and can be used in the research of breast cancer[1].

Product Specifications

CAS Number

[1497439-74-3]

UNSPSC

12352005

Target

RSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ad-8007.html

Purity

99.36

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@@H](N)C1CC1)N2CC(C3=CC=CC=C3)(C4=CC=CC=C4)CCC2

Molecular Formula

C22H26N2O

Molecular Weight

334.45

References & Citations

[1]Esquea E, et al. Discovery of novel brain permeable human ACSS2 inhibitors for blocking breast cancer brain metastatic growth. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573073.|[2]Esquea E, et al. Discovery of novel brain permeable human ACSS2 inhibitors for blocking breast cancer brain metastatic growth. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573073.