OX04529

OX04529 (compound 69) is a potent, selective and orally active agonist of GPR84. OX04529 inhibits FSK-induced cAMP production with an EC50 of 0.0185 nM. OX04529 displayed excellent potency, high G-protein signaling bias[1].

Product Specifications

UNSPSC

12352005

Target

GPR84

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ox04529.html

Solubility

10 mM in DMSO

Smiles

[O-][N+]1=CC(CCCC2=CC=C(C(C(F)(F)F)=C2)Cl)=CC(O)=C1

Molecular Formula

C15H13ClF3NO2

Molecular Weight

331.72

References & Citations

[1]Wang P, et al. Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists. J Med Chem. 2024 Jan 11;67 (1) :110-137.