Topoisomerase I inhibitor 12
Selected Variant
HY-161082
Size: 1 Each
Topoisomerase I inhibitor 12 (compound 12), a Camptothecin -based derivative, is a potent Topoisomerase I inhibitor. Topoisomerase I inhibitor 12 shows anticancer activity[1].
Product Specifications
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-i-inhibitor-12.html
Solubility
10 mM in DMSO
Smiles
O=C1N2C(N(CCN3CCOCC3)C(/C2=C\C4=CC=CC=C4)=O)=NC5=CC=CC=C51
Molecular Formula
C23H22N4O3
Molecular Weight
402.45
References & Citations
[1]Ahmed I. Khodair, et al. Camptothecin structure simplification elaborated new imidazo[2,1-b]quinazoline derivative as a human topoisomerase I inhibitor with efficacy against bone cancer cells and colon adenocarcinoma. European Journal of Medicinal Chemistry. 16 December 2023, 116049.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
Price
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