TDI-8304
Product Specifications
UNSPSC Description
TDI-8304, a macrocyclic peptide, is a potent, species selective, and noncovalent Plasmodium falciparum (Pf20S) inhibitor. TDI-8304 shows highly selective for Pf20S over human proteasomes[1].
Target Antigen
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tdi-8304.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@H](N2C(CCC2)=O)CC3=CC=CC(OCCCC[C@H](NC([C@@H](N1)CCN4CCOCC4)=O)C(NC5CCCC5)=O)=C3
Molecular Weight
597.75
References & Citations
[1]Hao-Chi Hsu, et al. Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nat Commun. 2023 Dec 14;14(1):8302.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161079/TDI-8304-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161079/
Clinical Information
No Development Reported
CAS Number
2307262-96-8
Curated Selection
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