KTt-45

KTt-45 is a T-type calcium channel blocker. KTt-45 has anticancer effect by inducing apoptosis on HeLa cervical cancer cell line[1].

Product Specifications

CAS Number

[2244987-60-6]

UNSPSC

12352005

Target

Apoptosis; Calcium Channel; Caspase

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ktt-45.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C/C=C(CC)/CC)C(O)=C(C(CC(C2=CC=CC=C2O)O3)=O)C3=C1

Molecular Formula

C22H24O5

Molecular Weight

368.42

References & Citations

[1]Du N H, et al. KTt-45, a T-type calcium channel blocker, acts as an anticancer agent by inducing apoptosis on HeLa cervical cancer cell line [J]. Scientific Reports, 2023, 13 (1) : 22092.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Caspase 3; Caspase 9; T-type calcium channel

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