HACE2/SP-IN-1

HACE2/SP-IN-1 (compound 7a) is a dual inhibitor of hACE2 and coronavirus spike protein. hACE2/SP-IN-1 can bind to the spike protein and block cell entry, preventing SARS-CoV-2 from infecting human cells[1].

Product Specifications

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE) ; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hace2-sp-in-1.html

Solubility

10 mM in DMSO

Smiles

O=[N+]([O-])C(C=C1)=CC=C1/C=N/C2=C(C3=CC=CC=C3)N=C4N2C=CC=N4

Molecular Formula

C19H13N5O2

Molecular Weight

343.34

References & Citations

[1]Azzouzi M, et al. Design, synthesis, and computational studies of novel imidazo[1,2-a]pyrimidine derivatives as potential dual inhibitors of hACE2 and spike protein for blocking SARS-CoV-2 cell entry. J Mol Struct. 2023 Aug 5;1285:135525.