PDH E1-IN-1
PDH E1-IN-1 (compound 24) is a selective TPP-competitive PDH E1 with an IC50 value of 0.99 μM[1].
Product Specifications
UNSPSC
12352005
Target
PDHK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pdh-e1-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=NC=C(C(N)=N1)CC2=CSC(CCNC3(C4=CC=C(C=C4)OC)COC3)=C2C
Molecular Formula
C23H28N4O2S
Molecular Weight
424.56
References & Citations
[1]Alex H Y Chan, et al. Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase. Bioorg Med Chem Lett. 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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