PLK1-IN-8
PLK1-IN-8 (compound TE6) is a PLK1 inhibitor, and inhibits cell proliferation by blocking the cell cycle at G2 phase. PLK1-IN-8 shows anticancer activity in vivo[1].
Product Specifications
UNSPSC
12352005
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plk1-in-8.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=C1C2=C3C(C)=C(CSC4=NN=C(C5=CC=C([N+]([O-])=O)C=C5)O4)O2)C3=O
Molecular Formula
C22H13N3O6S
Molecular Weight
447.42
References & Citations
[1]Zhang S, et al. A novel L-shaped ortho-quinone analog as PLK1 inhibitor blocks prostate cancer cells in G2 phase. Biochem Pharmacol. Published online December 3, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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