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EGFR-IN-92

EGFR-IN-92 (compound 15) is an allosteric T790M/L858R double mutant EGFR inhibitor. EGFR-IN-92 shows antiproliferative activity against H1975 non-small lung cancer (NSCLC) cancer cells expressing double mutant EGFR[1].

Product Specifications

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-92.html

Solubility

10 mM in DMSO

Smiles

[O-][N+](C1=CC(NC(C2=C(C)NC3=C2C=CC=C3)C4=C(O)C=CC=C4)=CC=C1)=O

Molecular Formula

C22H19N3O3

Molecular Weight

373.40

References & Citations

[1]Francesca Foschi, et al. Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :239-245.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1

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