DHP-B

DHP-B possesses anti-cancer activity and induces apoptosis. DHP-B covalently binds to Cys96 of CPT1A, blocks FAO, and disrupts the mitochondrial CPT1A-VDAC1 interaction, leading to increased mitochondrial permeability and reduced oxygen consumption and energy metabolism in CRC cells. DHP-B can be isolated from the plant Peperomia dindygulensis[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dhp-b.html

Solubility

10 mM in DMSO

Smiles

COC1=C2C(OCO2)=CC([C@@H](C3=CC(OC)=C(OC)C(OC)=C3)[C@@]4([H])COC(C4=C)=O)=C1

Molecular Formula

C23H24O8

Molecular Weight

428.43

References & Citations

[1]Anni Hu, A novel CPT1A covalent inhibitor modulates fatty acid oxidation and CPT1A-VDAC1 axis with therapeutic potential for colorectal cancer. Redox Biol. 2023 Dec:68:102959.