JAK1/TYK2-IN-4
JAK1/TYK2-IN-4 is a dual inhibitor of JAK and TYK2, with IC50s of 39 nM and 21 nM, respectively. JAK1/TYK2-IN-4 has oral bioavailability[1].
Product Specifications
CAS Number
2734918-33-1
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak1-tyk2-in-4.html
Solubility
10 mM in DMSO
Smiles
CC1=C(N2CCC3(C(NCC3)=O)CC2)N=C(NC4=CN(C)N=C4)N=C1
Molecular Formula
C17H23N7O
Molecular Weight
341.41
References & Citations
[1]Xue Cui, et al. Therapeutic potential of a synthetic dual JAK1/TYK2 inhibitor in inflammatory bowel disease. Int Immunopharmacol. 2023 Nov 20:126:111238.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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