Spire2-FMN2 PPI-IN-1

Spire2/FMN2 PPI-IN-1 (Compound 13) is a selective inhibitory fragment targeting the Spire2-FMN2 interaction, with an IC50 of 62 μM. Spire2/FMN2 PPI-IN-1 has affinity for KIND2, with a Kd of 87.7 μM, and does not inhibit KIND1. Spire2/FMN2 PPI-IN-1 can be used for the development of chemical probes for the Spire2-FMN2 interaction[1].

Product Specifications

CAS Number

[1557337-03-7]

UNSPSC

12352005

Target

Arp2/3 Complex

Type

Reference compound

Related Pathways

Cytoskeleton

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/spire2-fmn2-interaction-in-1.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C2C(N=CC=C2NCCN)=C1

Molecular Formula

C11H12FN3

Molecular Weight

205.23

References & Citations

[1]Radoslaw Kitel, et al. Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction. J Med Chem. 2023 Dec 14;66 (23) :15715-15727.