DHFR-IN-13
DHFR-IN-13 (Compd Hit8) is an active R. solani DHFR inhibitor with an IC50 value of 10.2 μM. DHFR-IN-13 has selectivity of inhibition against human DHFR with an IC50 value of 227.7 μM. DHFR-IN-13 also is a fungicide. DHFR-IN-13 has high antifungal activity against R. solani with EC50 value of 38.2 mg/L[1].
Product Specifications
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-13.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(F)C=C(N2[C@]3(C(N4C5=C3C=C(OCC)C=C5[C@@H](C)CC4(C)C)=O)SCC2=O)C=C1
Molecular Formula
C24H24ClFN2O3S
Molecular Weight
474.98
References & Citations
[1]Feng R, et al. Discovery of Novel Rhizoctonia solani DHFR Inhibitors as Fungicides Using Virtual Screening. J Agric Food Chem. 2023 Dec 13;71 (49) :19385-19395.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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