VU6021625
VU6021625 is a selective antagonist muscarinic acetylcholine receptors (mAChRs), with the IC50 value of 0.44 nM, 57 nM for human M4 and rat M4, respectively[1].
Product Specifications
CAS Number
2803696-99-1
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu6021625.html
Solubility
10 mM in DMSO
Smiles
[H][C@@](C1)(CN(C2)CC3CCOCC3)[C@@]2([H])C[C@H]1NC4=CC=C(C5=CC6=CN(C)N=C6C=C5)N=N4
Molecular Formula
C25H32N6O
Molecular Weight
432.56
References & Citations
[1]Mark S Moehle, et al. Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy. ACS Pharmacol Transl Sci. 2021 Aug 2;4 (4) :1306-1321.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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