Alatrofloxacin

Alatrofloxacin, the parenteral proagent of Trovafloxacin, is a fluoronaphthyridone which contains an L-alanyl-L-alanyl salt. Alatrofloxacin functions similar to other fluoroquinolone antibiotics in that it not only has antibiotic activity to kill invading organisms by interfering with DNA synthesis, it possesses immunosuppressive activity[1].

Product Specifications

CAS Number

[146961-76-4]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Antibiotic; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alatrofloxacin.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=CC(F)=C(N3C[C@@]4([H])[C@@]([C@@H]4NC([C@H](C)NC([C@@H](N)C)=O)=O)([H])C3)N=C2N(C5=C(C=C(C=C5)F)F)C=C1C(O)=O

Molecular Formula

C26H25F3N6O5

Molecular Weight

558.51

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Hall IH, et al. Effects of alatrofloxacin, the parental prodrug of trovafloxacin, on phagocytic, anti-inflammatory and immunomodulation events of human THP-1 monocytes. Biomed Pharmacother. 2003;57 (8) :359-365.