AR/BET protein degrader-1
AR/BET protein degrader-1 (Compound 149) is an Androgen Receptor and BET (bromodomain and extra-terminal domain) protein degrader that can be used in cancer research[1].
Product Specifications
CAS Number
[2571123-81-2]
UNSPSC
12352005
Target
Androgen Receptor; Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ar-bet-protein-degrader-1.html
Solubility
10 mM in DMSO
Smiles
CC1=NOC(C)=C1C2=CC=C(C)C(N(C[C@@H]3CC[C@@H](CNC4=CC(C(N(C5CCC(NC5=O)=O)C6=O)=O)=C6C=C4)CC3)C7=CC=C(C8(C#N)CC8)C=C7)=C2
Molecular Formula
C43H44N6O5
Molecular Weight
724.85
References & Citations
[1]Lyu Haibin, et al. Aromatic Amine Ar and Bet Targeted Protein Degradation Chimeric Compound and Application Thereof. CN-111944012-A
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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