EP300/CBP-IN-1
EP300/CBP-IN-1 (compound 172) is a potent EP300/CBP inhibitor with IC50s of 2.3 nM and 2.1 nM for CBP BRD and EP300 BRD, respectively. EP300/CBP-IN-1 has the inhibitory effect on the proliferation of prostate cancer CWR22RV1 cells[1].
Product Specifications
CAS Number
2638507-71-6
UNSPSC
12352005
Target
Epigenetic Reader Domain; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ep300-cbp-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=CC(F)=C(C=C2)Cl)[C@@H](CCO1)C3=NC4=CC(C5=C(C)ON=C5C)=CC=C4N3[C@H]6CC[C@@H](CC6)OCC
Molecular Formula
C30H32ClFN4O4
Molecular Weight
567.05
References & Citations
[1]Lei Fan, et al. An EP300/CBP inhibitor. CN112574189A.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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