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HSV-60mer (sodium)

HSV-60mer sodium is a 60 bp double-stranded oligonucleotide containing viral DNA motifs that derive from the herpes simplex virus 1 (HSV-1) genome[1]. Transfected HSV-60 has been shown to potently induce IFN-β in a Toll-like receptor (TLR) -, DNA-dependent activator of IRFs (DAI) -, and RNA polymerase III (Pol III) -independent, but STING-, TBK1- and IFN regulatory factor 3 (IRF3) -dependent manner.

Product Specifications

UNSPSC

12352208

Target

HSV; STING

Type

Oligonucleotides

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hsv-60mer-sodium.html

Purity

98.11

Solubility

10 mM in H2O

Smiles

[HSV-60mer(sodium)]

Molecular Weight

36939.88

References & Citations

[1]Unterholzner L, Keating SE, Baran M, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 2010;11 (11) :997-1004.|[2]Zhang Z, Yuan B, Bao M, Lu N, Kim T, Liu YJ. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells [published correction appears in Nat Immunol. 2012 Feb;13 (2) :196]. Nat Immunol. 2011;12 (10) :959-965.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Oligonucleotides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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