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KIO-301

KIO-301 is a photoswitchable HCN channel blocker, and can be used as the vitreous “light switch” molecule that reactivates retinitis pigmentosa[1].

Product Specifications

CAS Number

[1643463-61-9]

UNSPSC

12352005

Target

HCN Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kio-301.html

Solubility

10 mM in DMSO

Smiles

O=C(C[N+](CC)(CC)CC)NC1=CC=C(C=C1)/N=N/C2=CC=C(N(CC)CC3=CC=CC=C3)C=C2.[Br-]

Molecular Formula

C29H38BrN5O

Molecular Weight

552.55

References & Citations

[1]drughunter.com. Small Molecules of the Month. November 2023

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-160209/KIO-301-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-160209/

Scientific Category

Reference compound1

Clinical Information

Phase 2

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