SerSA

SerSA is a potent inhibitor of seryl-tRNA synthetases. SerSA inhibits EcSerRS, SaSerRS and HsSerRS with IC50s of 0.21, 0.23 and 2.17 μM, respectively[1].

Product Specifications

CAS Number

[299437-44-8]

UNSPSC

12352005

Target

Aminoacyl-tRNA Synthetase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/sersa.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1COS(NC([C@@H](N)CO)=O)(=O)=O

Molecular Formula

C13H19N7O8S

Molecular Weight

433.40

References & Citations

[1]Cain R, et al. Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. J Med Chem. 2019 Nov 14;62 (21) :9703-9717.