SerSA
SerSA is a potent inhibitor of seryl-tRNA synthetases. SerSA inhibits EcSerRS, SaSerRS and HsSerRS with IC50s of 0.21, 0.23 and 2.17 μM, respectively[1].
Product Specifications
CAS Number
[299437-44-8]
UNSPSC
12352005
Target
Aminoacyl-tRNA Synthetase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sersa.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1COS(NC([C@@H](N)CO)=O)(=O)=O
Molecular Formula
C13H19N7O8S
Molecular Weight
433.40
References & Citations
[1]Cain R, et al. Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. J Med Chem. 2019 Nov 14;62 (21) :9703-9717.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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