TDP-43 degrader-1
TDP-43 degrader-1 (Compound example 7) is a TDP-43 degrader. TDP-43 degrader-1 reduces the aggregation of TDP-43-positive HuR stress granules in cells and promotes the relocalization of abnormally distributed TDP-43 in the cytoplasm to the nucleus. TDP-43 degrader-1 can be used in the study of amyotrophic lateral sclerosis and Alzheimer's disease[1].
Product Specifications
CAS Number
[2902692-25-3]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tdp-43-degrader-1.html
Purity
95.00
Solubility
10 mM in DMSO
Smiles
CN1C(C(C(/C=C/C2C3=CC(OC)=C(OCC4=CC=CC=C4)C=C3CCN2)=C1)=C5)=NC=C5OC
Molecular Formula
C28H29N3O3
Molecular Weight
455.55
References & Citations
[1]Solas Dennis, et al. Preparation of substituted isoquinolines for the treatment of ALS. United States, US20230037538 A1 2023-02-09
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Lentiviral mouse Ubr4 shRNA (UAS) - Lentiviral mouse Ubr4 shRNA (UAS, RFP) plasmid
Beta-1,3-N-Acetylglucosaminyltransferase 3 (b3GNT3), Recombinant, Human, His-Tag