2′-Deoxy-4′-thiocytidine
2′-Deoxy-4′-thiocytidine (T-dCyd) is a novel epigenetic agent. 2′-Deoxy-4′-thiocytidine administrations led to a significant p21 increase. 2′-Deoxy-4′-thiocytidine can eradicate of tumor cells in the double-mutant xenografts[1].
Product Specifications
CAS Number
134111-30-1
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-deoxy-4-thiocytidine.html
Solubility
10 mM in DMSO
Smiles
O=C(N=C(N)C=C1)N1[C@@H]2S[C@H](CO)[C@@H](O)C2
Molecular Formula
C9H13N3O3S
Molecular Weight
243.28
References & Citations
[1]Sherry X Yang, et al. TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models. J Hematol Oncol. 2021, 14, 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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