AP1153 aptamer (sodium)
AP1153 aptamer sodium is a DNA aptamer that specifically binds to the cholecystokinin receptor CCKBR (Kd: ~15 pM), but does not activate CCKBR-related signaling pathways. AP1153 aptamer sodium is internalized by pancreatic ductal adenocarcinoma (PDAC) cells in a receptor-mediated manner. AP1153 aptamer sodium can bioconjugate to the surface of fluorescent nanoparticles to facilitate nanoparticle delivery to PDAC tumors in vivo[1].
Product Specifications
UNSPSC
12352208
Target
Cholecystokinin Receptor
Type
Oligonucleotides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ap1153-aptamer-sodium.html
Solubility
10 mM in DMSO
Smiles
[AP1153aptamer(sodium)]
References & Citations
[1]Clawson GA, Abraham T, Pan W, Tang X, Linton SS, McGovern CO, Loc WS, Smith JP, Butler PJ, Kester M, Adair JH, Matters GL. A Cholecystokinin B Receptor-Specific DNA Aptamer for Targeting Pancreatic Ductal Adenocarcinoma. Nucleic Acid Ther. 2017 Feb;27 (1) :23-35.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Frequently Asked Questions
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