XIAP BIR2/BIR2-3 inhibitor-3
XIAP BIR2/BIR2-3 inhibitor-3 is a dual inhibitor of BIR2 and BIR2-3 with IC50s less than 1 nM. XIAP BIR2/BIR2-3 inhibitor-3 can used in study cancers[1].
Product Specifications
CAS Number
1434125-52-6
UNSPSC
12352005
Target
IAP
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xiap-bir2-bir2-3-inhibitor-3.html
Solubility
10 mM in DMSO
Smiles
CN[C@@H](C)C(N[C@@H](C(C)(C)C)C(N1[C@@]2([H])C[C@@](N3C=C(COC4=CC=C(C[C@H](NC([C@@H](NC([C@]5([H])C[C@](CN5C([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)([H])N6C=C(N=N6)COC7=CC=C(C[C@H](NC([C@@H](NC2=O)CC8=CC=CC9=C8C=CC=C9)=O)C(NS(=O)(C%10CC%10)=O)=O)C=C7)=O)CC%11=CC=CC%12=C%11C=CC=C%12)=O)C(NS(=O)(C%13CC%13)=O)=O)C=C4)N=N3)([H])C1)=O)=O
Molecular Formula
C86H106N18O16S2
Molecular Weight
1712.00
References & Citations
[1]Benjamin Adam Seigal, et al. Macrocyclic compounds for inhibition of inhibitors of apoptosis. EP2776409B1. 2014-09-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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