RORγt agonist 4
Product Specifications
UNSPSC Description
RORγt agonist 4 (compound 14) is a potent and selective agonist of RORγt. RORγt agonist 4 significantly enhances metabolic stability. RORγt agonist 4 improves the situation of tumor models of mouse B16F10 melanoma and LLC lung adenocarcinoma[1].
Target Antigen
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-agonist-4.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(OC(C)C)C=CC(C2=C(C=C(NC(CC3=CC=C(S(=O)(CC)=O)C=C3)=O)C=C2Cl)Cl)=C1
Molecular Weight
531.45
References & Citations
[1]Lu L, et al. Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy. J Med Chem. 2023 Nov 20.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160021/RORγt-agonist-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160021/
Clinical Information
No Development Reported
CAS Number
2241769-59-3
Curated Selection
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