ET516
ET516 is a potent inhibitor of Androgen Receptor. ET516 significantly inhibits the proliferation and tumor growth of prostate cancer cells expressing AR-resistant mutants[1].
Product Specifications
CAS Number
[2820120-95-2]
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/et516.html
Purity
99.13
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC(C(C)(C)C2=CC=C(C=C2)C#CC3=CN=C(NS(=O)(C)=O)N=C3)=CC(Cl)=C1OCCCl
Molecular Formula
C25H22Cl2N4O3S
Molecular Weight
529.44
References & Citations
[1]Xie J, et al. Targeting androgen receptor phase separation to overcome antiandrogen resistance. Nat Chem Biol. 2022 Dec;18 (12) :1341-1350.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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