LGB321 (monohydrochloride)

LGB321 monohydrochloride is a potent, selective, orally active and ATP competitive inhibitor of all three PIM kinases. LGB321 monohydrochloride inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in a number of cell lines derived from diverse hematologic malignancies. LGB321 monohydrochloride can be used for the research of hematologic malignancies[1].

Product Specifications

CAS Number

[1469925-36-7]

UNSPSC

12352005

Target

MTOR; Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lgb321-monohydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C(N4C[C@@H](N)[C@H](O)[C@@H](C)C4)C=CN=C3.[H]Cl

Molecular Formula

C23H23ClF3N5O2

Molecular Weight

493.91

References & Citations

[1]Garcia PD, et al. Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers. Clin Cancer Res. 2014 Apr 1;20 (7) :1834-45.