LGB321 (monohydrochloride)
LGB321 monohydrochloride is a potent, selective, orally active and ATP competitive inhibitor of all three PIM kinases. LGB321 monohydrochloride inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in a number of cell lines derived from diverse hematologic malignancies. LGB321 monohydrochloride can be used for the research of hematologic malignancies[1].
Product Specifications
CAS Number
1469925-36-7
UNSPSC
12352005
Target
MTOR; Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lgb321-monohydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C(N4C[C@@H](N)[C@H](O)[C@@H](C)C4)C=CN=C3.[H]Cl
Molecular Formula
C23H23ClF3N5O2
Molecular Weight
493.91
References & Citations
[1]Garcia PD, et al. Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers. Clin Cancer Res. 2014 Apr 1;20 (7) :1834-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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