Cis- (Z) -Flupentixol (dihydrochloride)

Cis- (Z) -Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively[1][2].

Product Specifications

CAS Number

[51529-01-2]

Product Name Alternative

Cis- (Z) -Flupenthixol (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cis-z-flupentixol-dihydrochloride.html

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

OCCN1CCN(CC/C=C2C3=C(SC4=C\2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1.[H]Cl.[H]Cl

Molecular Formula

C23H27Cl2F3N2OS

Molecular Weight

507.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Jennifer M Wenzel, et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol Biochem Behav. 2013 Dec;114-115:90-6.|[2]Philip Seeman, et al. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47 (1) :27-38.