Nemorubicin (GMP)
Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin. Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity[1][2][3][4].
Product Specifications
CAS Number
108852-90-0
Product Name Alternative
Methoxymorpholinyl doxorubicin (GMP) ; FCE 23762 (GMP) ; PNU 152243 (GMP)
UNSPSC
12352005
Target
G-quadruplex
Type
GMP Small Molecules
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nemorubicin-gmp.html
Solubility
10 mM in DMSO
Smiles
COC1=C2C(C(C3=C(O)C(C[C@](C(CO)=O)(O)C[C@]4([H])O[C@H]5C[C@H](N6CCO[C@H](OC)C6)[C@H](O)[C@H](C)O5)=C4C(O)=C3C2=O)=O)=CC=C1
Molecular Formula
C32H37NO13
Molecular Weight
643.64
References & Citations
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
gamma Adducin (ADD3) (NM_016824) Human Recombinant Protein
