Nemorubicin (GMP)
Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin. Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity[1][2][3][4].
Product Specifications
CAS Number
108852-90-0
Product Name Alternative
Methoxymorpholinyl doxorubicin (GMP) ; FCE 23762 (GMP) ; PNU 152243 (GMP)
UNSPSC
12352005
Target
G-quadruplex
Type
GMP Small Molecules
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nemorubicin-gmp.html
Solubility
10 mM in DMSO
Smiles
COC1=C2C(C(C3=C(O)C(C[C@](C(CO)=O)(O)C[C@]4([H])O[C@H]5C[C@H](N6CCO[C@H](OC)C6)[C@H](O)[C@H](C)O5)=C4C(O)=C3C2=O)=O)=CC=C1
Molecular Formula
C32H37NO13
Molecular Weight
643.64
References & Citations
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
Frequently Asked Questions
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