YH16899
YH16899 binds Lysyl-tRNA synthetase (KRS), and inhibits membrane translocation of KRS. YH16899 impares the interaction of KRS with 67LR. YH16899 inhibits tumor metastasis in mouse models[1].
Product Specifications
CAS Number
[1428623-14-6]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Aminoacyl-tRNA Synthetase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yh16899.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(C(F)(F)F)=C1)/N=C2N(C(CC)C(O)=O)C3=CC(F)=C(F)C=C3S/2
Molecular Formula
C19H13F5N2O3S
Molecular Weight
444.38
Precautions
P261-P280-P302+P352
References & Citations
[1]Kim DG, et al. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Nat Chem Biol. 2014 Jan;10 (1) :29-34.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15782/YH16899-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15782/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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