A 419259 (GMP)
A 419259 GMP is the GMP grade A 419259 , inducing cell apoptosis. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. A 419259 (RK-20449) is a broad-spectrum pyrrole-pyrimidine inhibitor targeting Src, Lck, and Lyn with IC50s of 9 nM,[2].
Product Specifications
CAS Number
364042-47-7
Product Name Alternative
RK-20449 (GMP)
UNSPSC
12352005
Target
Apoptosis; Src
Type
GMP Small Molecules
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a-419259-gmp.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1
Molecular Formula
C29H34N6O
Molecular Weight
482.63
References & Citations
[1]Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21 (53) :8075-88.|[2]Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13 (3 Pt A) :379-89.
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from moisture and light
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
HA751582 100 µL
Phospho-PKC alpha/beta II (T638/T641) Recombinant Rabbit monoclonal Antibody
Sign In for Pricing
View Details 
E-UNEL-M0091-01 5x 96 Tests
Uncoated Mouse gp130 (Glucoprotein 130) ELISA Kit
Sign In for Pricing
View Details E-UNEL-M0091-02 15x 96 Tests
Uncoated Mouse gp130 (Glucoprotein 130) ELISA Kit
Sign In for Pricing
View Details 