A 419259 (GMP)

A 419259 GMP is the GMP grade A 419259 (HY-15764), inducing cell apoptosis. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. A 419259 (RK-20449) is a broad-spectrum pyrrole-pyrimidine inhibitor targeting Src, Lck, and Lyn with IC50s of 9 nM, [1][2].

Product Specifications

CAS Number

[364042-47-7]

Product Name Alternative

RK-20449 (GMP)

UNSPSC

12352005

Target

Apoptosis; Src

Type

GMP Small Molecules

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/a-419259-gmp.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1

Molecular Formula

C29H34N6O

Molecular Weight

482.63

References & Citations

[1]Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21 (53) :8075-88.|[2]Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13 (3 Pt A) :379-89.