PROTAC (H-PGDS) -8
PROTAC (H-PGDS) -8 is a Hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degrader, with a IC50 of 0.14 μM[1].
Product Specifications
CAS Number
2761281-51-8
UNSPSC
12352005
Target
Prostaglandin Receptor; PROTACs
Type
Reference compound
Related Pathways
GPCR/G Protein; PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/protac-h-pgds-8.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CCN(CC1)C2=CC=C(C=C2)NC(C3=CN=C(N=C3)OC4=CC=CC=C4)=O)N5CCN(CC5)C6=C(C7=CC=C6)C(N(C7=O)C8CCC(N(C8=O)C)=O)=O
Molecular Formula
C41H40N8O7
Molecular Weight
756.81
References & Citations
[1]Yokoo H, et al. Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design. J Med Chem. 2021 Nov 11;64 (21) :15868-15882.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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