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KDRLKZ-1

KDRLKZ-1 is a KLHDC2 ligand (Kd = 0.36 μM), with IC50s of 0.21 μM and 0.31 μM in alphaLISA and time-resolved fluorescence resonance energy transfer (TR-FRET) displacement assays[1].

Product Specifications

Product Name Alternative

8SGE

UNSPSC

12352005

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/kdrlkz-1.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CN1C=C(N2C(C(CC(C)C)=CC3=C2CN(C(OCCOC)=O)CC3)=O)C=CC1=O

Molecular Formula

C23H29N3O7

Molecular Weight

459.49

References & Citations

[1]Hickey CM, et al. Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat Struct Mol Biol. 2024 Jan 4.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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