KDRLKZ-1
KDRLKZ-1 is a KLHDC2 ligand (Kd = 0.36 μM), with IC50s of 0.21 μM and 0.31 μM in alphaLISA and time-resolved fluorescence resonance energy transfer (TR-FRET) displacement assays[1].
Product Specifications
Product Name Alternative
8SGE
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/kdrlkz-1.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CN1C=C(N2C(C(CC(C)C)=CC3=C2CN(C(OCCOC)=O)CC3)=O)C=CC1=O
Molecular Formula
C23H29N3O7
Molecular Weight
459.49
References & Citations
[1]Hickey CM, et al. Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat Struct Mol Biol. 2024 Jan 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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