NLRP3-IN-29
NLRP3-IN-29 (Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) . NLRP3-IN-29 has the potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. NLRP3-IN-29 can be used for research on Alzheimer's disease[1].
Product Specifications
CAS Number
[2198483-40-6]
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-29.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C1=CC=C(C=C1)S(=O)(NC(NC2=CC=CC3=C2C=CC=C3)=O)=O)C
Molecular Formula
C21H22N2O3S
Molecular Weight
382.48
References & Citations
[1]Kim EY, et al. Structure-based design and synthesis of sulfonylureas as novel NLRP3 inhibitors for Alzheimer's disease. Bioorg Med Chem Lett. 2024 Jan 19;99:129622.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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