NLRP3-IN-29

NLRP3-IN-29 (Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) . NLRP3-IN-29 has the potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. NLRP3-IN-29 can be used for research on Alzheimer's disease[1].

Product Specifications

CAS Number

[2198483-40-6]

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nlrp3-in-29.html

Solubility

10 mM in DMSO

Smiles

CC(C)(C1=CC=C(C=C1)S(=O)(NC(NC2=CC=CC3=C2C=CC=C3)=O)=O)C

Molecular Formula

C21H22N2O3S

Molecular Weight

382.48

References & Citations

[1]Kim EY, et al. Structure-based design and synthesis of sulfonylureas as novel NLRP3 inhibitors for Alzheimer's disease. Bioorg Med Chem Lett. 2024 Jan 19;99:129622.